一种紫外光3d打印用海藻酸水凝胶基质的制备方法

Preparation method of alginic acid hydrogel matrix for UV 3D printing

Abstract

本发明涉及一种水凝胶基质的制备方法,特别是一种紫外光3D打印用海藻酸水凝胶基质制备方法,属于生物材料制备技术领域。本发明是通过在冷冻干燥法制得的海藻酸钠分子链上接枝烯基基团,经溶解、混合制备得到紫外光3D打印用海藻酸水凝胶基质。本发明的制备方法采用混合溶剂环境下的冷冻干燥工艺,大大提高海藻酸钠的接枝率,完全克服因接枝率低下引起的紫外固化速度慢的问题。本发明制备得到的紫外光3D打印用海藻酸水凝胶基质,在紫外光的照射下迅速凝胶保持形态,并且在低浓度金属卤化物的存在下,体系能进一步后固化,提高其水凝胶强度,完全克服现有3D打印水凝胶的塑性难、塌缩的问题。本发明制备方法简单、成本低,易工业化生产。
The invention relates to a preparation method of a hydrogel matrix, especially a preparation method of an alginic acid hydrogel matrix for UV 3D printing, and belongs to the technical field of biological material preparation. According to the preparation method, alkenyl groups are grafted on the molecular chains of sodium alginate prepared by a freeze-dry method, and after dissolving and mixing, the alginic acid hydrogel matrix for UV 3D printing is obtained. The preparation method adopts a freeze-drying technology under mixed solvent environment, the grafting rate of sodium alginate is largely improved, and the problem that the UV curing speed is slow due to low grafting rate is completely solved. The prepared alginic acid hydrogel matrix can rapidly solidify under the irradiation of UV light, the solid state can be maintained, moreover, in the presence of low concentration metal halides, the system can be further solidified, the hydrogel strength is improved, and the problems of conventional 3D printing hydrogel such as difficult moulding, collapse, and the like are overcome. The preparation method is simple, the cost is low, and the preparation method can be applied to industry easily.

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Patent Citations (3)

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