Pi3k inhibitor for treatment of respiratory disease

用于治疗呼吸疾病的pi3k抑制剂

Abstract

本发明涉及作为磷酸肌醇3’OH激酶家族(以下为PI3K)的活性或功能的抑制剂的化合物及其药学上可接受的盐,其用于在具有PI3Kδ突变的患者中治疗或预防呼吸道感染、治疗气道损伤和/或预防气道受损。
The present invention is directed to compounds and pharmaceutically acceptable salts thereof which are inhibitors of the activity or function of the phosphoinositide 3'OH kinase family (hereinafter PI3K) for use in the treatment or prevention of respiratory infections, the treatment of airway damage, and/or the prevention of airway injury in patients with a PI3K Delta mutation.

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Patent Citations (3)

    Publication numberPublication dateAssigneeTitle
    CN-102459253-AMay 16, 2012葛兰素集团有限公司Oxazole substituted indazoles as pi3-kinase inhibitors
    WO-2012032067-A1March 15, 2012Glaxo Group LimitedPolymorphes et sels de n-[5-[4-(5-{[(2r,6s-2,6-diméthyl-4-morpholinyl]- méthyl}-1,3-oxazol-2-yl)-1h-indazol-6-yl]-2-(méthyloxy)-3-pyridinyl]- méthanesulfonamide
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